District Results of Presidential Elections 2000 for Sene
| Candidate | Votes | Percentage (%) |
| Mills | 16344 | 75.5 |
| Kuffuor | 4310 | 19.9 |
| Goosie | 425 | 2 |
| Hagan | 139 | 0.6 |
| Mahama | 131 | 0.6 |
| Wereko Brobby | 0 | 0 |
| Lartey | 308 | 1.4 |
| Valid | 0 | 0 |
| Rejected | 0 | 0 |
| Total Turnout | 0 | 0 |
| Registered | 0 |